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Published TCIMAIL newest issue No.197
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CAS RN: 1180-71-8 | Product Number: L0258
Limonin
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Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
76,00 €
|
1 | 5 |
|
| 1G |
476,00 €
|
1 | 25 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0258 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__0O__8 = 470.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1180-71-8 |
| Reaxys Registry Number | 1695716 |
| PubChem Substance ID | 253661951 |
| Merck Index (14) | 5494 |
| MDL Number | MFCD00075922 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 95.0 area% |
| Specific rotation [a]20/D | -116 to -120 deg(C=1, Acetone) |
Properties (reference)
| Melting Point | 298 °C |
| Specific Rotation | -117° (C=1,Acetone) |
| Maximum Absorption Wavelength | 285 nm |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Tetrahydrofuran, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | RR1122000 |
Transport Information:
| HS Number | 2932209090 |
Application
Limonin: A Chemically-Induced Carcinogenesis Inhibitor and a HIV-1 Replication Inhibitor
Limonin is a non-volatile triterpeneis which is one of two major bitter principles in citrus juice, especially in grapefruit juice. Limonin has been found to inhibit chemical induced carcinogenesis. Limonin is an inducer of glutathione S-transferase, a major detoxifying enzyme system. Additionally, limonin has been reported to inhibit in vitro HIV-1 protease activity.
References
- Limonin and limonoids. Chemistry, biochemistry, and juice bitterness (a review)
- Limonin and nomilin inhibitory effects on chemical-induced tumorigenesis (a review)
- Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin
- Antioxidant Activity of Citrus Limonoids, Flavonoids, and Coumarins
- Suppression of colon carcinogenesis by bioactive compounds in grapefruit
- Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells
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