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Published TCIMAIL newest issue No.197
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CAS RN: 53956-04-0 | Product Number: G0151
Monoammonium Glycyrrhizinate
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Purity: >75.0%(HPLC)
Synonyms:
- Glycyrrhizic Acid Monoammonium Salt
- Glycyrrhizin Monoammonium Salt
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
16,00 €
|
Contact Us | 31 |
|
| 25G |
72,00 €
|
2 | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | G0151 |
| Purity / Analysis Method | >75.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__2H__6__5NO__1__6 = 839.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 53956-04-0 |
| Related CAS RN | 563-96-2&207300-84-3 |
| Reaxys Registry Number | 3897076 |
| PubChem Substance ID | 87570349 |
| MDL Number | MFCD00167400 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 75.0 area% |
| Specific rotation [a]20/D | +45.0 to +52.0 deg(C=1.5, 40%EtOH)(calcd.on anh.substance) |
| Water | max. 10.0 % |
Properties (reference)
| Melting Point | 217 °C |
| Specific Rotation | 49° (C=1.5,EtOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
| EC Number | 258-887-7 |
| RTECS# | LZ6500000 |
Transport Information:
| HS Number | 2938903010 |
Application
Monoammonium Glycyrrhizinate: An Ammonium Salt of a Triterpenoid Saponin Glycyrrhizin
Monoammonium glycyrrhizinate is an ammonium salt of glycyrrhizin [G0150] which is the major triterpenoid saponin of licorice root (Glycyrrhiza glabra). It has been widely used for the treatment of various inflammatory-based skin diseases. Therefore, its various delivery systems have been reported.1-3) It is also an agonist of the human sweet taste receptor4), and is known to be a natural sweetener. It is dissolved in an organic solvent such as DMSO and dimethyl formamide, and also dissolved in organic solvent-free aqueous buffers relatively stably in a pH range from 7 to 9.5) (The product is for research purpose only.)
References
- 1) Ethosomes for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers
- 2) Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate
- 3) Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: Human and murine models
- 4) Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells
- 5) Monoammonium glycyrrhizinate stability in aqueous buffer solutions
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