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Published TCIMAIL newest issue No.197
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CAS RN: 6990-06-3 | Product Number: F1007
Fusidic Acid
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Purity: >97.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€98.00
|
1 | 6 |
|
| 5G |
€313.00
|
Contact Us | 4 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F1007 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__1H__4__8O__6 = 516.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6990-06-3 |
| Reaxys Registry Number | 2197692 |
| PubChem Substance ID | 253660799 |
| Merck Index (14) | 4317 |
| MDL Number | MFCD00865135 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | -6.0 to -10.0 deg(C=1,CHCl3) |
Properties (reference)
| Melting Point | 193 °C |
| Specific Rotation | -7° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 204(H2O) nm |
| Solubility (soluble in) | Dioxane, Alcohol, Chloroform, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 230-256-0 |
| RTECS# | RC1350000 |
Transport Information:
| HS Number | 2941900000 |
Application
Fusidic Acid: An Inhibitor of the Elongation Factor G (EF-G)
Fusidic acid, a steroidal antibiotic agent, is derived from the fungus Fusidium coccineum. The elongation factor G (EF-G) catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Fusidic acid binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. Fusidic acid is mainly notable for its activity against staphylococci, whether or not they are resistant to methicillin and related penicillins.
References
- Structure-activity relationships in fusidic acid-type antibiotics (a review)
- The antimicrobial activity of fusidic acid (a review)
- Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics (a review)
- Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site
- Dumb and dumber-the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus (a review)
- Characterization of Global Patterns and the Genetics of Fusidic Acid Resistance (a review)
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