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Published TCIMAIL newest issue No.197
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CAS RN: 15307-86-5 | Product Number: D3748
2-(2,6-Dichloroanilino)phenylacetic Acid
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Purity: >98.0%(GC)(T)
Synonyms:
- Diclofenac
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€69.00
|
7 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D3748 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__4H__1__1Cl__2NO__2 = 296.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 15307-86-5 |
| Reaxys Registry Number | 2146636 |
| PubChem Substance ID | 87561265 |
| Merck Index (14) | 3081 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 158 °C(dec.) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 239-348-5 |
| RTECS# | AG6310000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2922498590 |
Application
DNA aptamer research
Reference
- ssDNA aptamers that recognize diclofenac and 2-anilinophenylacetic acid
Application
Diclofenac: A Non-Selective Non-Steroidal Anti-Inflammatory Drug (NSAID)
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. It is a non-selective cyclooxygenase (COX) inhibitor. COX directs the formation of several key mediators of inflammation called prostaglandins. Thus, diclofenac reduces the synthesis of prostaglandins. Diclofenac is metabolized principally by CYP2C9. Diclofenac is often used as a potassium salt (immediate-release) or sodium salt [D2508] (delayed-release). In addition, diclofenac and its metabolites are reportedly often detected in waste waters, since diclofenac is a common pharmaceutical agent. (The product is for research purpose only.)
References
- Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs
- Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy (a review)
- Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy (a review)
- The metabolism of diclofenac - enzymology and toxicology perspectives (a review)
- Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry
- Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography
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