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Published TCIMAIL newest issue No.197
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CAS RN: 57-41-0 | Product Number: D0894
Phenytoin
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Purity: >99.0%(T)
Synonyms:
- 5,5-Diphenylhydantoin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€39.00
|
5 | 25 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D0894 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__1__5H__1__2N__2O__2 = 252.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 57-41-0 |
| Reaxys Registry Number | 384532 |
| PubChem Substance ID | 87567495 |
| SDBS (AIST Spectral DB) | 7403 |
| Merck Index (14) | 7322 |
| MDL Number | MFCD00005264 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Solubility in Acetone | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 298 °C |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Acetone, Alcohol |
| Solubility (insoluble in) | Chloroform, Benzene, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 200-328-6 |
| RTECS# | MU1050000 |
Transport Information:
| HS Number | 2933210090 |
Application
Phenytoin: A Sodium Channel Blocking Agent
Phenytoin is one of the major antiepileptic agents. The mechanisms of action have not been established. However, it has been suggested that its activity in epilepsy is related to involve the voltage-dependent blockade of membrane sodium channels resulting in a reduction in sustained high-frequency neuronal discharges. (The product is for research purpose only.)
References
- Phenytoin: mechanisms of its anticonvulsant action (a review)
- Basis of the antiseizure action of phenytoin (a review)
- Pharmacokinetic drug interactions with phenytoin (part I) (a review)
- Pharmacokinetic drug interactions with phenytoin (part II) (a review)
- Simultaneous determination of lamotrigine, phenobarbitone, carbamazepine and phenytoin in human serum by high-performance liquid chromatography
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