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Published TCIMAIL newest issue No.197
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CAS RN: 110-87-2 | Product Number: D0555
3,4-Dihydro-2H-pyran
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Purity: >97.0%(GC)
Synonyms:
- DHP
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25ML |
€18.00
|
Contact Us | 32 |
|
| 100ML |
€40.00
|
11 | 11 |
|
| 500ML |
€109.00
|
4 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D0555 |
| Purity / Analysis Method | >97.0%(GC) |
| Molecular Formula / Molecular Weight | C__5H__8O = 84.12 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 110-87-2 |
| Reaxys Registry Number | 103493 |
| PubChem Substance ID | 87567211 |
| SDBS (AIST Spectral DB) | 2119 |
| MDL Number | MFCD00006558 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 97.0 % |
Properties (reference)
| Boiling Point | 86 °C |
| Flash point | -6 °C |
| Specific Gravity (20/20) | 0.93 |
| Refractive Index | 1.44 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H225 : Highly flammable liquid and vapour. |
| Precautionary Statements | P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 : Keep container tightly closed. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. |
Related Laws:
| EC Number | 203-810-4 |
Transport Information:
| UN Number | UN2376 |
| Class | 3 |
| Packing Group | II |
| HS Number | 2932990090 |
Application
THP Protection of Alcohols
Typical Procedure :THP protection of (R)-(+)-glycidol
(R = (R)-(+)-glycidyl) : Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
(R = (R)-(+)-glycidyl) : Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
References
- A Facile Synthesis of (S)-Felodipine
PubMed Literature
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