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Published TCIMAIL newest issue No.197
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CAS RN: 482577-59-3 | Product Number: C2475
N-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine Methyl Ester Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€70.00
|
1 | 12 |
|
| 25G |
€166.00
|
1 | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2475 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2N__2O__2·HCl = 358.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 482577-59-3 |
| Related CAS RN | 137863-89-9 |
| PubChem Substance ID | 160871372 |
| MDL Number | MFCD08460094 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +17.0 to +21.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 187 °C(dec.) |
| Specific Rotation | 19° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2926907090 |
Application
A Key Synthetic Intermediate of Valsartan
This product has been used as a key synthetic intermediate of valsartan [V0112] which is an antagonist of the angiotensin II AT1-receptor subtype.
References
- Synthesis of Valsartan via Decarboxylative Biaryl Coupling
- An Efficient and Telescopic Process for Valsartan, an Angiotensin II Receptor Blocker
- Stability-indicating UPLC method for determination of Valsartan and their degradation products in active pharmaceutical ingredient and pharmaceutical dosage forms
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