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Published TCIMAIL newest issue No.197
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CAS RN: 56-25-7 | Product Number: C0019
Cantharidin
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Purity: >98.0%(GC)
Synonyms:
- exo-1,2-cis-Dimethyl-3,6-epoxyhexahydrophthalic Anhydride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
107,00 €
|
1 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C0019 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2O__4 = 196.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 56-25-7 |
| Reaxys Registry Number | 85302 |
| PubChem Substance ID | 125308680 |
| Merck Index (14) | 1752 |
| MDL Number | MFCD00134968 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 215.0 to 219.0 °C |
Properties (reference)
| Melting Point | 217 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-263-3 |
| RTECS# | RN8575000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2932990090 |
Application
Cantharidin: A Strong Inhibitor of Protein Phosphatases Types 1 (PP1) and 2A (PP2A)
Cantharidin is a toxic terpenoid compound in the blood of blister beetles. Cantharidin acts as a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A) which are enzymes that remove a phosphate group from the phosphorylated amino acid residue of its substrate protein. Cantharidin has been used to reat warts and molluscum as a traditional medicine. Recently, several studies have demonstrated that cantharidin has anticancer, antibiotic, antivirus activities and immune-regulated functions. (The product is for research purpose only.)
References
- Cantharidin-binding protein: Identification as protein phosphatase 2A
- Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A
- Molecular modes of action of cantharidin in tumor cells
- Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways
- The effects of cantharidin and cantharidin derivates on tumour cells (a review)
- Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery (a review)
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