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CAS RN: 280744-09-4 | Product Number: B5716
SB 216763
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€55.00
|
1 | 28 |
|
| 50MG |
€175.00
|
1 | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5716 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__2Cl__2N__2O__2 = 371.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 280744-09-4 |
| Reaxys Registry Number | 11333014 |
| PubChem Substance ID | 354335732 |
| MDL Number | MFCD09753369 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 104 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Research on regenerative medicine
SB 216763 can maintain mESCs in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibrobrasts (MEFs).1) 1 promotes the generation of hematopoietic stem cells (HSCs) in aorta-gonad-mesonephros (AGM) explants.2)
References
- 1) Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells
- 2) Hematopoietic stem cell development requires transient Wnt/β-catenin activity
Application
SB 216763: An ATP-Competitive Inhibitor of GSK-3α
SB 216763 is reportedly an ATP-competitive inhibitor of glycogen synthase kinase-3α (GSK-3α) in vitro with an IC50 value of 34 nM. GSK-3 is a serine/threonine protein kinase, and inhibition of its activity has been proposed to play a role in the regulation of numerous signalling pathways that elicit cellular responses.
References
- Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
- Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death
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