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CAS RN: 301836-41-9 | Product Number: B4003
SB 431542
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Purity: >97.0%(HPLC)
Synonyms:
- 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€184.00
|
1 | ≥60 |
|
| 100MG |
€528.00
|
1 | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4003 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__6N__4O__3 = 384.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 301836-41-9 |
| Reaxys Registry Number | 9086247 |
| PubChem Substance ID | 468590503 |
| MDL Number | MFCD05865244 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 214 °C(dec.) |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
SB-431542: A Selective Inhibitor TGF-β Type I Receptor Kinase
SB-431542 is a selective inhibitor (or an antagonist) of the transforming growth factor-β superfamily type I (TGF-β type I) receptor kinase. It has been reported that SB-431542 suppresses the proliferation of tumor cells, and evaluates the differential ability of ES and iPS cells.
References
- SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
- Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type i receptor kinase activity: SB-431542
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells
- 3つの小分子化合物を用いてヒトiPS細胞の分化能力を促進する基盤技術を開発
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