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Published TCIMAIL newest issue No.197
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CAS RN: 170449-18-0 | Product Number: A3666
AG 1478 Hydrochloride
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Purity: >95.0%(T)(HPLC)
Synonyms:
- N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine Hydrochloride
- N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€55.00
|
Contact Us | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3666 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4ClN__3O__2·HCl = 352.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 170449-18-0 |
| Reaxys Registry Number | 7452865 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 235 °C |
GHS
Related Laws:
Transport Information:
Application
AG 1478 Hydrochloride: An EGFR Tyrosine Kinase Inhibitor
Epidermal Growth Factor Receptor (EGFR) is a type of receptor found in cells that plays a role in various cancer-related processes such as cell proliferation, apoptosis, angiogenesis and metastasis. Increased expression of EGFR is often seen in various types of tumors and has become an important target for cancer therapy. AG 1478 hydrochloride is an EGFR tyrosine kinase inhibitor used in laboratory cancer studies. (The product is for research use only.)
References
- Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors epidermal growth factor receptors
- EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells
- Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478
- Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase
Product Documents (Note: Some products will not have analytical charts available.)
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