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CAS RN: 129639-79-8 | Product Number: A3213
Abafungin
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Purity: >95.0%(HPLC)
Synonyms:
- N-[4-[2-(2,4-Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine
- 4-[2-(2,4-Dimethylphenoxy)phenyl]-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€105.00
|
Contact Us | 3 |
|
| 250MG |
€339.00
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3213 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2N__4OS = 378.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 129639-79-8 |
| Reaxys Registry Number | 11337934 |
| PubChem Substance ID | 468590172 |
| MDL Number | MFCD00942263 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 197.0 to 201.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 199 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934100090 |
Application
Abafungin: A Thiazole Type Antifungal Agent with a Novel Mechanism of Action
Abafungin is a broad-spectrum thiazole type antifungal agent with a novel mechanism of action. Mode of action studies suggested that inhibits the enzyme sterol-C-24-methyltransferase which catalyzes the transmethylation at the C-24 position of the sterol side chain. In addition, abafungin directly impairs the fungal cell membrane.
References
- Modes of Action of the New Arylguanidine Abafungin beyond Interference with Ergosterol Biosynthesis and in vitro Activity against Medically Important Fungi
- Thiazoles: a valuable insight into the recent advances and biological activities (a review)
- Bioactive thiazole and benzothiazole derivatives (a review)
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