Published TCIMAIL newest issue No.196
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CAS RN: 63547-13-7 | Product Number: A3194
Adrafinil
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Purity: >98.0%(N)
Synonyms:
- 2-(Benzhydrylsulfinyl)-N-hydroxyacetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€42.00
|
1 | 12 |
|
| 100MG |
€133.00
|
1 | 8 |
|
| 1G |
€841.00
|
1 | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3194 |
| Purity / Analysis Method | >98.0%(N) |
| Molecular Formula / Molecular Weight | C__1__5H__1__5NO__3S = 289.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 63547-13-7 |
| Reaxys Registry Number | 1990030 |
| PubChem Substance ID | 354335694 |
| Merck Index (14) | 170 |
| MDL Number | MFCD00865357 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 151.0 to 154.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 153 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | < 1 g/l |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 264-303-1 |
| RTECS# | AB8139500 |
Transport Information:
| HS Number | 2930909899 |
Application
Adrafinil: A Synthetic Psychostimulant Agent Banned by the World Anti-Doping Agency
Adrafinil is a synthetic psychostimulant agent and a prodrug of modafinil [CAS: 68693-11-8] that is a wakefulness-promoting agent used for treatment of disorders such as narcolepsy and shift work sleep disorder. The precise mechanisms of action are still unknown. Modafinil has weak to negligible interactions with receptors for norepinephrine, serotonin, dopamine, etc. Modafinil was widely believed to serve as a selective α1-adrenergic receptor agonist. Recent work, however, in vitro, modafinil binds to the dopamine transporter and inhibits dopamine reuptake. This activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals.
Adrafinil was sometimes used as a stimulatory agent in athletes, and were added to the prohibited list established by the World Anti-Doping Agency (WADA) in 2008. Therefore, the effective detection of adrafinil and its metabolites in human urine has been studied. (The product is for research purpose only.)
Adrafinil was sometimes used as a stimulatory agent in athletes, and were added to the prohibited list established by the World Anti-Doping Agency (WADA) in 2008. Therefore, the effective detection of adrafinil and its metabolites in human urine has been studied. (The product is for research purpose only.)
References
- Adrafinil: a novel vigilance promoting agent (a review)
- Adrafinil: effects on behavior and cognition in aged canines (a review)
- LC-ESI-MS determination and pharmacokinetics of adrafinil in rats
- Doping control analysis for adrafinil and its major metabolites in human urine
- Development of a validated LC method for enantiomeric separation and determination of adrafinil and its related substances on a Chiralcel OJ-H column connected to PDA and polarimetric detectors in series
- Fluorescent zinc and copper complexes for detection of adrafinil in paper-based microfluidic devices
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