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CAS RN: 152-72-7 | Product Number: A3186
Acenocoumarol
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Purity: >98.0%(HPLC)
Synonyms:
- 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
79,00 €
|
2 | 24 |
|
| 250MG |
251,00 €
|
Contact Us | 36 |
|
| 1G |
680,00 €
|
11 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3186 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__5NO__6 = 353.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 152-72-7 |
| Reaxys Registry Number | 1269370 |
| PubChem Substance ID | 468590161 |
| Merck Index (14) | 29 |
| MDL Number | MFCD00137816 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.50 to 4.50 % |
| Melting point | 196.0 to 200.0 °C |
Properties (reference)
| Melting Point | 197 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 9.39 mg/l 20 - 25 °C |
| Solubility (soluble in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 205-807-3 |
| RTECS# | GN4900000 |
Transport Information:
| HS Number | 2932209090 |
Application
Aacenocoumarol: A Coumarin Vitamin K Antagonist
Aacenocoumarol and warfarin [W0005], coumarin derivatives, are vitamin K antagonists. They exhibit their anticoagulant effect by inhibition of vitamin K epoxide reductase. They also interfere with the production of vitamin K-dependent coagulation factors II, VII, IX, and X and proteins C and S. They reduce blood clotting by reducing the action of vitamin K. Acenocoumarol is used as an oral anticoagulant prescribed for the treatment of a variety of thromboembolic disorders such as atrial fibrillation and thrombosis or embolism. (The product is for research purpose only.)
References
- Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol (a review)
- Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon (a review)
- HPLC determination of warfarin and acenocoumarol in raw materials and pharmaceuticals
- Determination of coumarin-type anticoagulants in human plasma by HPLC-electrospray ionization tandem mass spectrometry with an ion trap detector
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