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CAS RN: 133550-35-3 | Product Number: A2704
Tyrphostin AG 494
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Purity: >98.0%(HPLC)(N)
Synonyms:
- (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
74,00 €
|
1 | 38 |
|
| 100MG |
253,00 €
|
1 | 28 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2704 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2N__2O__3 = 280.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 133550-35-3 |
| Reaxys Registry Number | 4322707 |
| PubChem Substance ID | 253661368 |
| MDL Number | MFCD00209863 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 249 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2926907090 |
Application
Tyrphostin AG 494: A Potent and Selective Inhibitor of EGF Receptor (EGFR) Tyrosine Kinase
Tyrphostin AG 494, a member of tyrosine kinase inhibitors, is a potent and selective inhibitor of EGF receptor (EGFR) tyrosine kinase.
References
- Tyrphostins. II. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
- Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins.
- Tyrphostin AG 494 blocks Cdk2 activation
- Tyrphostins Protect Neuronal Cells from Oxidative Stress
- Receptor-Guided Alignment-Based Comparative 3D-QSAR Studies of Benzylidene Malonitrile Tyrphostins as EGFR and HER-2 Kinase Inhibitors
- The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells
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