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Published TCIMAIL newest issue No.197
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CAS RN: 762-72-1 | Product Number: A0729
Allyltrimethylsilane
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25ML |
€48.00
|
12 | 15 |
|
| 250ML |
€299.00
|
2 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0729 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__6H__1__4Si = 114.26 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 762-72-1 |
| Reaxys Registry Number | 906755 |
| PubChem Substance ID | 87562275 |
| SDBS (AIST Spectral DB) | 5609 |
| MDL Number | MFCD00008635 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 83 °C |
| Flash point | 7 °C |
| Specific Gravity (20/20) | 0.72 |
| Refractive Index | 1.41 |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H225 : Highly flammable liquid and vapour. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 : Keep container tightly closed. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. |
Related Laws:
| EC Number | 212-104-5 |
Transport Information:
| UN Number | UN1993 |
| Class | 3 |
| Packing Group | II |
| HS Number | 2931900090 |
Application
TCI Practical Example: Hosomi-Sakurai Allylation via an Imine Intermediate
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Used Chemicals
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Procedure
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Cyclopentanone (890 µL, 10 mmol), benzyl carbamate (1.81 g, 12 mmol) and allyltrimethylsilane (2.2 mL, 14 mmol) were dissolved in dichloromethane (14 mL). After cooling to 0 °C, BF3·Et2O (1.51 mL, 12 mmol) was added and the reaction mixture was stirred for 21 hours at room temperature. After the reaction, the mixture was washed with strd. NaHCO3 aq. (10 mL), brine (20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 9:1) to afford benzyl (1-allylcyclopentyl)carbamate (1.84 g, 71% yield) as a clear yellow liquid.
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Experimenter’s Comments
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The reaction solution was monitored by UPLC.
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Analytical Data
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Benzyl (1-Allylcyclopentyl)carbamate
1H NMR (400 MHz, CDCl3); δ 7.35-7.29 (m, 5H), 5.82-5.72 (m, 1H), 5.06-5.02 (m, 4H), 4.68 (brs, 1H), 2.52-2.51 (m, 2H), 1.76-1.61 (m, 8H).
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Other Reference
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- Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines
Application
9-Aminocamptothecin (9-AC): A Water Insoluble Topoisomerase-I Inhibitor
References
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Oxidative Esterification of Aldehydes to Hexafluoroisopropyl (HFIP) Esters Using an Oxoammonium Salt
References
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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