Published TCIMAIL newest issue No.197
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RhoA Transcriptional Signaling Inhibitor
No.177(April 2018)
CCG-1423 (1) is an inhibitor of Rho signaling.1) The target molecule is myocardin-related transcription factor A (MRTF-A).2) 1 inhibits MRTF-A binding to importin α/β1.
Mouse embryonic stem cells (mESCs) are differentiated to BMP-7-positive cells by treatment in combination with 1 and a PI3K inhibitor, LY294002.3) The combination of these small molecules is also used for differentiation of human induced pluripotent stem cells (iPSCs) to renal progenitors.4)
BMP-7: Bone morphogenetic protein-7
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References
- 1)CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling
- 2)RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling
- 3)Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells
- 4)Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury
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