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Published TCIMAIL newest issue No.197
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Fluorescent Probe
No.164(January 2015)
FITC dextran (fluorescein isothiocyanate-labeled dextran) is a pH-dependent lysosomal probe1,2) and has been applied to the visualization of lysosomes.3-5) FITC dextran has been used for studies on endocytic processes not only in mammal but also in yeast.6,7)
Lysosomal storage disorders (LSDs), which are defects in the lysosomal enzymes, lead to a progressive accumulation of un-degraded substrates or catabolic products that are unable to escape from the organelle.8) About 50 different clinical entities of LSDs have been genetically identified.9) Recently, the application of FITC dextran extended research for bioconjugates to target lysosomes.10)
The dextran moiety (1) is a FITC-labeled dextran with Mw. = ca. 10,000.
References
- 1)Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
- 2)Identification and characterization of a proton pump on lysosomes by fluorescein isothiocyanate-dextran fluorescence
- 3)Microspectrofluorometry by digital image processing: Measurement of cytoplasmic pH
- 4)FITC-dextran as a probe for endosome function and localization in kidney
- 5)Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells
- 6)Endocytosis in Saccharomyces cerevisiae: Internalization of α-amylase and fluorescent dextran into cells
- M. Makarow, EMBO J. 1985, 4, 1861.
- 7)Transport of a fluorescent macromolecule via endosomes to the vacuole in Saccharomyces cerevisiae
- 8)Lysosomal disorder
- 9)Advances in the treatment of lysosomal storage disease
- 10)Screening and optimization of ligand conjugates for lysosomal targeting
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