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Published TCIMAIL newest issue No.197
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Beaucage Reagent
Recently, there have been many studies of the use of hosphorothioate DNA for as antisense DNA in antivirus agents in which the DNA is not decomposed by nucleases. 3H-1,2-Benzodithiol-3-one 1,1-dioxide (1) efficiently introduces sulfur atom into phosphite 2, so that it can be converted to phosphorothioate 3.
References
- 1)Synthesis of oligonucleoside phosphorothioates
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