Propolis (bee glue) is a mixture of tree resins and dyes collected from plants by honey bees, and their own secretion. Honey bees use it as a building material of the beehive, while humans have used its antibacterial and antitumor activities from B. C. E.
Caffeic acid phenethyl ester (CAPE) is a constituent of propolis, which has various bioactivities. It has been reported that CAPE inhibits NF-κB activation and has antineoplastic, antioxidant, anti-inflammatory, and cytostatic properties.
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