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CAS RN: 152-11-4 | Product Number: V0118
Verapamil Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$57.00
|
Contact Us | Contact Us | ≥100 |
|
| 25G |
$189.00
|
13 | 1 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | V0118 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__8N__2O__4·HCl = 491.07 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 152-11-4 |
| Related CAS RN | 52-53-9 |
| Reaxys Registry Number | 3647093 |
| PubChem Substance ID | 253660291 |
| Merck Index (14) | 9950 |
| MDL Number | MFCD00055208 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 143.0 to 147.0 °C |
Properties (reference)
| Melting Point | 145 °C |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Ethanol, Methanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | YV8320000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2926.90.4801 |
Application
Lentivirus vector transduction enhancer
Verapamil increases transduction by VSV-G–pseudotyped lentiviral vectors.1)
References
- 1) ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells
Application
Verapamil Hydrochloride: The First Calcium-Channel Antagonist (Blocker)
Calcium channel antagonists (blockers) are chemicals that disrupt the movement of calcium ion (Ca2+) through calcium channels in the cell membrane. Verapamil hydrochloride, which is the first calcium channel antagonist, prolongs atrioventricular (A-V) conduction (A-H interval) in a dose-dependent manner. It is an effective antianginal agent when directly compared with a β-blocker, and is more effective in reducing myocardial ischemia compared with amlodipine monotherapy. Recently, various formulations have been reported to achieve efficient drug incorporation with a satisfactory in vitro drug release rate. (The product is for research purpose only.)
References
- Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem
- Verapamil (a review of its pharmacological properties and therapeutic use in coronary artery disease)
- The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres
- Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing
- Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads
PubMed Literature
Articles/Brochures
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Safety Data Sheet (SDS)
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Specifications
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