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CAS RN: 148893-10-1 | Product Number: R0295
Reagents for Condensation Reactions (HATU) (HPMC encapsulated)
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Purity:
Synonyms:
- HATU ca. 0.45 mmol/capsule (HPMC encapsulated)
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10EACH |
$60.00
|
Contact Us | Contact Us | 10 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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Supplemental Product Information:
Contents (per one capsule)
- HATU : ca. 0.45 mmol
Directions for Use
- Each capsule contains all reagents for a single use on 0.40 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine.
Typical condition: 0.40 mmol of carboxylic acid and 1.05 equiv. of amines and 1.5 equiv. of base in DMF (0.20 M) at 30 °C.
Related Products
- A1797 HATU
| Product Number | R0295 |
| Molecular Formula / Molecular Weight | C__1__0H__1__5F__6N__6OP = 380.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 148893-10-1 |
Specifications
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | min. 95.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P285 : In case of inadequate ventilation wear respiratory protection. P280 : Wear protective gloves. P272 : Contaminated work clothing must not be allowed out of the workplace. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse. P304 + P341: IF INHALED: If breathing is difficult, remove person to fresh air and keep comfortable for breathing. |
Related Laws:
Transport Information:
| HS Number | 3822.19.0080 |
Application
TCI Practical Example: The Condensation Reaction Using HATU in a Capsule Reagent
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Used Chemicals
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Procedure
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Reagents for condensation capsule (HATU) (one capsule) was added to a solution of 4-bromobenzoic acid (80 mg, 0.40 mmol, 1.0 eq.), morpholine (37 μL, 0.42 mmol, 1.05 eq.) and N,N-diisopropylethylamine (100 μL, 0.60mmol, 1.5 eq.) in DMF (2 mL) at r.t. and the mixture was stirred at 30 °C for 1 hour. The reaction solution was diluted with sat. Na2SO4 aq. (15 mL) and extracted with ethyl acetate (15 mL x 2). The organic layer was washed with 2 mol/L HCl aq. (15 mL), sat. NaHCO3 aq. (15 mL) and brine (15 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (hexane:ethylacetate = 2:1 - 1:1) to afford (4-bromophenyl)(morpholino)methanone (95 mg, 88% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes HATU (ca. 0.40 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
HPMC was removed with a saturated sodium sulfate solution, but during the separation, the separating funnel was clogged due to the precipitation of sodium sulfate. Therefore, the precipitated sodium sulfate was filtered off, and ethyl acetate was added to the filtrate for extraction. Use of a more dilute sodium sulfate solution may reduce clogging problems.
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Analytical Data
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(4-Bromophenyl)(morpholino)methanone
1H NMR (400 MHz, CDCl3); δ 7.57 (d, J = 8.4 Hz, 2H), 7.30 (d, J = 8.4 Hz, 2H), 3.74-3.44 (m, 8H).
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Lead Reference
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- Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
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Other Reference
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- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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