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CAS RN: 63208-82-2 | Product Number: P2751
Pifithrin-α
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$129.00
|
3 | 1 | ≥100 |
|
| 50MG |
$458.00
|
Contact Us | Contact Us | 37 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P2751 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__8N__2OS·HBr = 367.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 63208-82-2 |
| Reaxys Registry Number | 4943838 |
| PubChem Substance ID | 468592707 |
| Merck Index (14) | 7421 |
| MDL Number | MFCD00417851 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 192 °C |
GHS
Related Laws:
| RTECS# | KM5784250 |
Transport Information:
| HS Number | 2934.20.8000 |
Application
Mitophagy research
References
- Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
- Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
Application
Pifithrin-α (PFT-α): A p53 Inhibitor
p53 (Also known as Trp53 in mice, TP53 in humans) is a tumor suppressor protein that is frequently inactivated in tumors.1) Pifithrin-α (PFT-α) is a p53 inhibitor that blocks p53-dependent transcriptional activation and apoptosis.2-4) Other p53 Inhibitors: Cyclic Pifithrin-α Hydrobromide [C2826] and Pifithrin-μ [P2048].
References
- 1) Assessing TP53 status in human tumours to evaluate clinical outcome
- 2) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
- 3) Suppression of p53: a new approach to overcome side effects of antitumor therapy (a review)
- 4) Prospective therapeutic applications of p53 inhibitors (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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