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CAS RN: 30636-90-9 | Product Number: P2651
(20S)-Protopanaxadiol
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Purity: >95.0%(HPLC)
Synonyms:
- Dammar-24-ene-3β,12β,20-triol
- 20(S)-APPD
- 20-Epiprotopanaxadiol
- (3β,12β)-Dammar-24-ene-3,12,20-triol
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$209.00
|
Contact Us | Contact Us | Contact Us |
|
| 100MG |
$524.00
|
Contact Us | Contact Us | 20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2651 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__5__2O__3 = 460.74 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 30636-90-9 |
| Reaxys Registry Number | 3086791 |
| PubChem Substance ID | 468592653 |
| MDL Number | MFCD12032048 |
Specifications
| Appearance | White to Light yellow powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 211 °C |
| Specific Rotation | 21° (C=1,CHCl3) |
GHS
Related Laws:
| RTECS# | HB4083000 |
Transport Information:
| HS Number | 2906.19.5000 |
Application
(20S)-Protopanaxadiol: A Metabolic Derivative of Ginsenosides Used as an Apoptosis Inducer
(20S)-Protopanaxadiol is an aglycon metabolic derivative of ginsenosides (e.g. Rb1, Rc, Rd [G0550], and Rg3) which can be isolated from various plants, including Panax ginseng.1,2) It has been reported that (20S)-protopanaxadiol has a wide range of pharmacological effects, such as anti-cancer, anti-bacterial, and anti-depressant activities.1,3) In biological studies, (20S)-protopanaxadiol is used as an apoptosis inducer to induce cytotoxicity for human cancer cell lines.4-6) (The product is for research purpose only.)
References
- 1) Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
- 2) High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
- 3) 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests
- 4) Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
- 5) 20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells
- 6) Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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