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CAS RN: 34183-22-7 | Product Number: P2301
Propafenone Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$37.00
|
Contact Us | Contact Us | 11 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P2301 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__7NO__3·HCl = 377.91 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 34183-22-7 |
| Related CAS RN | 54063-53-5 |
| Reaxys Registry Number | 4343069 |
| PubChem Substance ID | 253660866 |
| Merck Index (14) | 7794 |
| MDL Number | MFCD00079243 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 171.0 to 175.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 173 °C |
| Maximum Absorption Wavelength | 303 nm (MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UH2833000 |
Transport Information:
| HS Number | 2922.50.1400 |
Application
Propafenone Hydrochloride: A Sodium Channel Antagonist (Blocker)
Propafenone hydrochloride is an orally active sodium channel antagonist (blocker). Propafenone works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells. Moreover, propafenone also has β-adrenoceptor antagonist, potassium channel antagonist, and weak calcium channel antagonist activity. Propafenone is used as a class Ic antiarrhythmic agent. (The product is for research purpose only.)
References
- Propafenone (a review on the pharmacology of the antiarrhythmic agent propafenone in humans and laboratory animals.)
- Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias (a review)
- Potassium channel blocking properties of propafenone in rabbit atrial myocytes
- Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry
PubMed Literature
Articles/Brochures
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