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CAS RN: 112529-15-4 | Product Number: P1901
Pioglitazone Hydrochloride
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$165.00
|
17 | 1 | 35 |
|
| 25G |
$494.00
|
2 | 1 | 31 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P1901 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__9H__2__0N__2O__3S·HCl = 392.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 112529-15-4 |
| Related CAS RN | 111025-46-8 |
| Reaxys Registry Number | 3579575 |
| PubChem Substance ID | 125307574 |
| SDBS (AIST Spectral DB) | 52915 |
| Merck Index (14) | 7452 |
| MDL Number | MFCD04975446 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 190.0 to 197.0 °C |
Properties (reference)
| Melting Point | 191 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2930.90.2900 |
Application
Pioglitazone Hydrochloride: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)
Pioglitazone hydrochloride, a thiazolidinedione, is an agonist at the peroxisome proliferator-activated receptor of the gamma subtype (PPARγ), a transcription-regulating receptor. PPAR receptors are found in peripheral tissues important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. Therefore, pioglitazone decreases insulin resistance in the periphery tissues and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. And recently, it has been reported that pioglitazone slows down the progression of Alzheimer's disease. For your reference, [A2567] is a key synthetic intermediate of pioglitazone. (The product is for research purpose only.)
References
- An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
- Synthesis and Biological Activity of Metabolites of the Antidiabetic, Antihyperglycemic Agent Pioglitazone
- Pioglitazone (a review)
- Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
- Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor γ agonist
- Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease
- Quantitative determination of pioglitazone in human serum by direct-injection high-performance liquid chromatography mass spectrometry and its application to a bioequivalence study
- インスリン抵抗性改善薬ピオグリタゾンの創製 (a review)
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