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CAS RN: 54-11-5 | Product Number: N0079
Nicotine
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Purity: >95.0%(GC)(T)
Synonyms:
- (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25ML |
$60.00
|
Contact Us | 4 | 23 |
|
| 100ML |
$180.00
|
Contact Us | 4 | 14 |
|
| 500ML |
$541.00
|
Contact Us | 1 | 8 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0079 |
| Purity / Analysis Method | >95.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2 = 162.24 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 54-11-5 |
| Reaxys Registry Number | 82109 |
| PubChem Substance ID | 87573472 |
| SDBS (AIST Spectral DB) | 6729 |
| Merck Index (14) | 6524 |
| MDL Number | MFCD00006369 |
Specifications
| Appearance | Colorless to Red to Green clear liquid |
| Purity(GC) | min. 95.0 % |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -160 to -173 deg(C=10, Acetone) |
Properties (reference)
| Melting Point | -80 °C |
| Boiling Point | 91 °C/3 mmHg |
| Flash point | 95 °C |
| Specific Gravity (20/20) | 1.02 |
| Specific Rotation | -167° (C=10,Acetone) |
| Refractive Index | 1.53 |
| Solubility in water | Completely miscible |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P391 : Collect spillage. P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | QS5250000 |
Transport Information:
| UN Number (DOT-AIR) | UN1654 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | II |
| HS Number | 2933.39.9200 |
Application
Nicotine: A Nicotinic Acetylcholine Receptors (nAChRs) Agonist
Nicotine (or (-)-(S)-nicotine) is an alkaloid and natural insecticide that acts as an anti-herbivore chemical in tobacco plants. Nicotine acts as a nicotinic acetylcholine receptors (nAChRs) agonist. nAChRs are a family of ligand-gated ion channels. Recent studies have shown that nicotine activates neuronal nAChRs in peripheral and central nervous systems leading to depolarization of cell membranes and elevation of intracellular calcium levels, which are considered to cause stimulation of neurotransmitter release, synaptic transmission, intracellular signal transduction and gene expression.1) Nicotine is also used as a probe agent for phenotyping cytochrome P450 2A6 (CYP2A6) which is involved in the metabolism of nicotine.2) (The product is for research purpose only.)
References
- 1) Mammalian nicotinic acetylcholine receptors: from structure to function (a review)
- 2) Metabolism and disposition kinetics of nicotine (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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