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CAS RN: 159857-80-4 | Product Number: M3224
MC-Val-Cit-PAB-OH
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Purity: >98.0%(HPLC)(N)
Synonyms:
- N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]hexanamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$281.00
|
1 | 1 | 11 |
|
| 500MG |
$845.00
|
Contact Us | Contact Us | 26 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3224 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__8H__4__0N__6O__7 = 572.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 159857-80-4 |
| Reaxys Registry Number | 15438807 |
| PubChem Substance ID | 468592347 |
| MDL Number | MFCD26142966 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2925.19.4200 |
Application
A Peptide Linker Designed for Antibody-Drug Conjugate (ADC)
This product is a peptide linker designed for Antibody-Drug Conjugate (ADC) which concept is to use an antibody to deliver a cytotoxic drug (payload) selectively to a target such as a tumor-associated antigen.
References
- Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity
- Antibody-Drug Conjugates for Cancer Therapy
- Design, Synthesis, and Biological Evaluation of Antibody-Drug Conjugates Comprised of Potent Camptothecin Analogues
Articles/Brochures
TCIMAIL
[Featured Products] Enzymatically Cleavable Linkers for Antibody-Drug Conjugates (ADCs)[TCIMAIL No.183] Dipeptides Degradable by Enzyme in Lysosome
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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