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CAS RN: 145525-41-3 | Product Number: M3177
Mitiglinide Calcium
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Purity:
Synonyms:
- (αS,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$32.00
|
1 | 1 | 18 |
|
| 500MG |
$129.00
|
Contact Us | Contact Us | 38 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | M3177 |
| Molecular Formula / Molecular Weight | C__3__8H__4__8CaN__2O__6 = 668.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 145525-41-3 |
| Reaxys Registry Number | 8027952 |
| PubChem Substance ID | 468592314 |
| Merck Index (14) | 6211 |
| MDL Number | MFCD09955408 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 97.0 % |
| Specific rotation [a]20/D | +5.0 to +9.0 deg(C=1, MeOH(calcd.on anh.substance)) |
| Water | 4.5 to 6.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 185 °C |
| Specific Rotation | 5.5° (C=1,MeOH) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.99.7500 |
Application
Mitiglinide Calcium: A Fast-Acting Insulin-Releasing Agent
Mitiglinide calcium (KAD-1229; s 21403) is a glitinide class non-sulfonylurea insulinotropic agent with rapid onset. More rapidly than that of sulfonylurea antidiabetics, mitiglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. For your reference, [O0471] is a synthetic intermediate of mitiglinide. (The product is for research purpose only.)
References
- Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.
- The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
- Effects of mitiglinide (s 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel
- Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus (a review)
- Simple, sensitive, and rapid LC-ESI-MS method for quantification of mitiglinide in human urine
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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