Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 338967-87-6 | Product Number: M3108
Mdivi-1
×
![]()
×
Purity: >95.0%(HPLC)
Synonyms:
- 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$80.00
|
Contact Us | Contact Us | 4 |
|
| 50MG |
$276.00
|
Contact Us | Contact Us | 17 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3108 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__0Cl__2N__2O__2S = 353.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 338967-87-6 |
| Reaxys Registry Number | 23802926 |
| PubChem Substance ID | 354335750 |
| MDL Number | MFCD00974506 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 289 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.59.8000 |
Application
Mdivi-1: A Selective Cell-Permeable Inhibitor of Mitochondrial Fission
Mitochondria play a key role in maintaining cellular metabolic homeostasis, and its fission and fusion play important roles in in several pathological conditions. Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp-1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders.
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
References
- Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
- Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
- Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine (a review)
- Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness (a review)
- Mitochondrial fission - a drug target for cytoprotection or cytodestruction? (a review)
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.