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CAS RN: 84088-42-6 | Product Number: L0270
Linomide
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Purity: >98.0%(HPLC)
Synonyms:
- 4-Hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Roquinimex
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$170.00
|
1 | Contact Us | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | L0270 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__6N__2O__3 = 308.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 84088-42-6 |
| Reaxys Registry Number | 8566168 |
| PubChem Substance ID | 354334061 |
| Merck Index (14) | 8259 |
| MDL Number | MFCD00866331 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 96.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2933.49.2600 |
Application
Roquinimex: An Immunostimulant, Angiogenesis Inhibitor and TNF-α Down-Regulator
Linomide (roquinimex, LS 2616) is a synthetic immunostimulant which increases natural killer (NK) cell activity and macrophage cytotoxicity. Linomide also inhibits angiogenesis and reduces the secretion of tumor necrosis factor-α (TNF-α). Linomide has been investigated as an anti-tumor agent and a type I antidiabetes agent. (The product is for research purpose only.)
References
- Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide)
- Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers
- Potentiation of the antiangiogenic ability of Linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers
- Structure-activity relationships studies of the anti-angiogenic activities of linomide
- The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus (a review)
- Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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