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CAS RN: 100986-85-4 | Product Number: L0193
Levofloxacin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$37.00
|
3 | 2 | ≥100 |
|
| 25G |
$111.00
|
13 | 1 | ≥100 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | L0193 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0FN__3O__4 = 361.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 100986-85-4 |
| Reaxys Registry Number | 5385660 |
| PubChem Substance ID | 87558890 |
| SDBS (AIST Spectral DB) | 51758 |
| Merck Index (14) | 6771 |
| MDL Number | MFCD00865049 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 222.0 to 230.0 °C |
| Specific rotation [a]20/D | -63.0 to -70.0 deg(C=5, CHCl3) |
Properties (reference)
| Melting Point | 224 °C |
| Specific Rotation | -66° (C=5,CHCl3) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UU8815550 |
Transport Information:
| HS Number | 2934.99.4400 |
Application
Levofloxacin: The Active (S)-(-)-Enantiomer of Ofloxacin, Fluoroquinolone Antimicrobial
Levofloxacin, a synthetic fluoroquinolone antimicrobial, is the active (S)-(-)-enantiomer of the racemic drug substance ofloxacin [O0403]. Levofloxacin has broad-spectrum bactericidal activity against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes. The mechanism of action of ofloxacin (and other fluoroquinolone) involves inhibition of bacterial topoisomerase IV and DNA gyrase (topoisomerases II), enzymes required for DNA replication, transcription, repair and recombination. For your reference, [L0238] is a key synthetic intermediate of levofloxacin. (The product is for research purpose only.)
References
- Synthesis and antibacterial activities of optically active ofloxacin
- In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin
- levofloxacin: a review of its antibacterial activity, pharmacokinetics and therapeutic efficacy
- Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin [C2227, C2510]
- Quinolones in 2005: an update (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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