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CAS RN: 139298-40-1 | Product Number: K0055
KN-93
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Purity: >98.0%(HPLC)
Synonyms:
- N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5MG |
$121.00
|
Contact Us | Contact Us | 28 |
|
| 25MG |
$419.00
|
Contact Us | Contact Us | 22 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | K0055 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__9ClN__2O__4S = 501.04 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 139298-40-1 |
| Reaxys Registry Number | 8357363 |
| PubChem Substance ID | 354335639 |
| MDL Number | MFCD00236424 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.00 to 6.00 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | DB1576070 |
Transport Information:
| HS Number | 2935.90.7500 |
Application
KN-93: A Potent and Specific Inhibitor of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
KN-93 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) which is a multifunctional serine/threonine kinase with numerous roles in human physiology. CaMKII mediates immediate effects due to phosphorylation of cellular proteins such as ion channels and calcium handling proteins.
References
- The newly synthesized selective calcium/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
- Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
- NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
- Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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