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CAS RN: 1392-21-8 | Product Number: K0046
Leucomycins
×
Purity:
Synonyms:
- Kitasamycin
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$50.00
|
2 | 1 | 14 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product has not been tested and guaranteed for potency.
| Product Number | K0046 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1392-21-8 |
| PubChem Substance ID | 87560725 |
| Merck Index (14) | 5453 |
| MDL Number | MFCD00147435 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| IR | confirm to structure |
| Purity(HPLC) | min. 48.0area% (A5+A4+A1) |
| Leucomycin A5 | 40.0 to 70.0 area% |
| Leucomycin A4 | 5.0 to 25.0 area% |
| Leucomycin A1 | 3.0 to 12.0 area% |
| Water | max. 3.0 % |
Properties (reference)
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| RTECS# | OH4550000 |
Transport Information:
| HS Number | 2941.90.1050 |
Application
Leucomycin (kitasamycin): A Mixture of 16-Membered Macrolide Substances Having Antibacterial Activity
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Leucomycin (other name: kitasamycin) is a mixture of 16-membered macrolide substances having antibacterial activity isolated from the broth filtrate of Streptomyces kitasatoensis. It has activity against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and rickettsiae. It inhibits bacterial protein synthesis both in vivo and in vitro. Recently, renewed interest in synthesis of 16-membered macrolide derivatives has been evoked by their interesting properties.
References
- Leucomycin, a new antibiotic
- T. Hata, Y. Sano, N. Ohki, Y. Yokoyama, A. Matsumae, S. Ito, J. Antibiot. [A] 1953, 6, 87.
- Cellular accumulation of macrolide antibiotics. Intracellular bioactivity (a review)
- Modifications and biological activity of natural and semisynthetic 16-membered macrolide antibiotics (a review)
- Determination of macrolide antibiotics in meat and fish by liquid chromatography-electrospray mass spectrometry
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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