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CAS RN: 172152-36-2 | Product Number: I1191
Ilaprazole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole
- 2-[[(4-Methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$138.00
|
Contact Us | Contact Us | 11 |
|
| 1G |
$345.00
|
Contact Us | Contact Us | 16 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | I1191 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__8N__4O__2S = 366.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 172152-36-2 |
| Reaxys Registry Number | 8859737 |
| MDL Number | MFCD00942538 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.39.9200 |
Application
Ilaprazole: A Proton Pump Inhibitor with Superior Pharmacological Profile
Ilaprazole (IY-81149) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD) and duodenal ulcer in clinical.1,2) Compared with all other PPIs, ilaprazole has shown an extended plasma half-life, a metabolism not significantly influenced by CYP2C19 genetic polymorphism and similar safety.2) Ilaprazole can be used with clarithromycin [C2220] and amoxicillin [A2099] as a triple therapy regimen for eradicating Helicobacter pylori.3) In addition, there are reports that PPIs including ilaprazole suppresses cancer growth.4) (The product is for research purpose only.)
References
- 1) General pharmacology of IY-81149, a new proton pump inhibitor
- 2) Ilaprazole for the treatment of gastro-esophageal reflux (a review)
- 3) Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study
- 4) Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase.
- 5) Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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