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CAS RN: 68047-06-3 | Product Number: H1693
(Z)-4-Hydroxytamoxifen
Purity: >95.0%(HPLC)
- (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol
- 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
---|---|---|---|---|---|
10MG |
$132.00
|
Contact Us | 1 | 26 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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Product Number | H1693 |
Purity / Analysis Method | >95.0%(HPLC) |
Molecular Formula / Molecular Weight | C__2__6H__2__9NO__2 = 387.52 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (<0°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
CAS RN | 68047-06-3 |
Reaxys Registry Number | 4910748 |
MDL Number | MFCD00468090 |
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Melting point | 152.0 to 156.0 °C |
NMR | confirm to structure |
Melting Point | 154 °C |
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
RTECS# | SL1210000 |
HS Number | 2922.19.7000 |
References
- Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes
- Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
- Oxidative metabolism of tamoxifen to Z-4-hydroxytamoxifen hydroxytamoxifen by cytochrome P450 isoforms: An appraisal of in vitro studies (a review)
- Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: The ‘personalised’ approach?
References
- Small molecule-triggered Cas9 protein with improved genome-editing specificity
- Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
- Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing
- HIT-Cas9: A CRISPR/Cas9 Genome-Editing Device under Tight and Effective Drug Control
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