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CAS RN: 364-98-7 | Product Number: D5402
Diazoxide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$81.00
|
1 | 1 | 8 |
|
| 1G |
$231.00
|
35 | 1 | 34 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D5402 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__7ClN__2O__2S = 230.67 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 364-98-7 |
| Reaxys Registry Number | 523846 |
| PubChem Substance ID | 354335417 |
| Merck Index (14) | 3004 |
| MDL Number | MFCD00078578 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 332 °C |
| Maximum Absorption Wavelength | 268(MeOH) nm |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Alcohol, Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | DK8185000 |
Transport Information:
| HS Number | 2934.99.3000 |
Application
Diazoxide: An ATP-Sensitive Potassium Channel (KATPt Channel) Activator with Multiple Effects
Diazoxide is an ATP-sensitive potassium channel (KATP channel) activator, which causes local relaxation in vascular smooth muscle1,2) and inhibits islet β-cell from secreting insulin.3) Therefore, diazoxide has been used as an antihypertensive agent and as a hyperglycemic agent. Diazoxide also acts as a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (also known as AMPA receptors) which are major players in mediating basal synaptic transmission and synaptic plasticity in the mammalian CNS.4) In addition, diazoxide affects other ion channels and ATPases, and may directly regulate mitochondrial energetics.5) (The product is for research purpose only.)
References
- Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels: possible mechanism of cardioprotection
- Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulfonylurea receptor
- Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells
- Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons
- Multiplicity of effectors of the cardioprotective agent, diazoxide (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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