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CAS RN: 364622-82-2 | Product Number: D5249
Doripenem Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$230.00
|
Contact Us | 2 | 25 |
|
| 250MG |
$686.00
|
Contact Us | Contact Us | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D5249 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__4N__4O__6S__2·H__2O = 438.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 364622-82-2 |
| Related CAS RN | 148016-81-3 |
| Reaxys Registry Number | 15340136 |
| PubChem Substance ID | 354335134 |
| MDL Number | MFCD09749887 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Specific rotation [a]20/D | +32.0 to +37.0 deg(C=1, H2O) |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.00 to 13.50 % |
Properties (reference)
| Melting Point | 173 °C(dec.) |
| Specific Rotation | 34° (C=1,H2O) |
GHS
Related Laws:
Transport Information:
| HS Number | 2935.90.9500 |
Application
Doripenem: A Carbapenem Antibiotic with Broad-Spectrum Activity
Doripenem (S-4661) is a carbapenem antibiotic with broad-spectrum activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains and Pseudomonad aeruginosa. Carbapenems, including doripenem, act fungicidally by inhibiting bacterial cell wall biosynthesis by binding to and inactivating penicillin-binding proteins (PBPs) which are essential enzymes for the biosynthesis. In addition, carbapenems are stable to most β-lactamases including AmpC β-lactamases and extended-spectrum β-lactamases. (The product is for research purpose only.)
References
- Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential
- Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various ＆beta;-lactamase resistance mechanisms
- Doripenem (a review)
- Comparative review of the carbapenems
- Quantification of doripenem in human plasma and peritoneal fluid by high-performance liquid chromatography with ultraviolet detection
- Characterization of the antibiotic doripenem using physicochemical methods - chromatography, spectrophotometry, spectroscopy and thermal analysis
- Stability-indicating RP-HPLC method for analysis of the antibiotic doripenem in pharmaceutical formulation -Comparison to UV spectrophotometry and microbiological assay
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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