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CAS RN: 848821-58-9 | Product Number: D3843
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Trimethylsilyl Ether
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Purity: >98.0%(GC)(T)
Synonyms:
- (S)-(-)-2-[Diphenyl(trimethylsilyloxy)methyl]pyrrolidine
- α,α-Diphenyl-L-prolinol Trimethylsilyl Ether
- (S)-Hayashi-Jorgensen Catalyst
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$201.00
|
1 | 1 | 1 |
|
| 5G |
$804.00
|
1 | Contact Us | 9 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D3843 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__0H__2__7NOSi = 325.53 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 848821-58-9 |
| Reaxys Registry Number | 10089429 |
| PubChem Substance ID | 354334880 |
| MDL Number | MFCD08690083 |
Specifications
| Appearance | White to Yellow to Green clear liquid |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -48.0 to -53.0 deg(C=1, CHCl3) |
Properties (reference)
| Specific Gravity (20/20) | 1.04 |
| Specific Rotation | -50° (C=1,CHCl3) |
| Refractive Index | 1.55 |
| Maximum Absorption Wavelength | 193 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.99.7900 |
Application
Organocatalysts for Asymmetric Michael Additional Reactions
References
- 1) Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
- 2) High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations
- 3) An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita?Baylis?Hillman Reaction
- 4) Enantioselective Organocatalytic Michael/Aldol Sequence: Anticancer Natural Product (+)-trans-Dihydrolycoricidine
Application
Asymmetric Organocatalyst
Experimental procedure3): The β-ketoester 2 (0.2 mmol) is added to a solution of 3 (0.02 mmol), benzoic acid (0.02 mmol), and the aldehyde 1 (0.6 mmol) in toluene (0.2 mL). After complete consumption of 2, usually within 14–18 h, the crude product is directly charged on to silica gel and subjected to flash chromatography (hexane:Et2O) to afford 4.
References
- 1)Enantioselective Organocatalyzed α Sulfenylation of Aldehydes
- 2)Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
- 3)An Unexpected Organocatalytic Asymmetric Tandem Michael/Morita–Baylis–Hillman Reaction
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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