Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 22978-25-2 | Product Number: C4016
GW 9662
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-5-nitro-N-phenylbenzamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$87.00
|
Contact Us | Contact Us | 33 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C4016 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__9ClN__2O__3 = 276.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 22978-25-2 |
| Reaxys Registry Number | 2749539 |
| MDL Number | MFCD01215270 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 159.0 to 163.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 161 °C |
GHS
Related Laws:
| RTECS# | CV2465500 |
Transport Information:
| HS Number | 2924.29.7790 |
Application
GW 9662: A Peroxisome Proliferator-Activated Receptor γ (PPARγ) Antagonist
Peroxisome proliferator-activated receptor γ (PPARγ) antagonist is a druggable target for the treatment of not only type 2 diabetes and obesity, but also cancer. It has been reported that the PPARγ antagonist GW9662 binds to the ligand binding site of PPARγ and results in the inhibition of adipocyte differentiation.1) GW9662 prevents the activation of PPARγ and inhibits the growth of human breast tumor cell lines.2,3) In addition, GW9662 stimulates the differentiation of M2c macrophages and induces the expression of growth arrest specific 6 (Gas6).4) (The product is for research use only.)
References
- 1) Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662
- 2) GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation
- 3) The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity (a review)
- 4) The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.