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CAS RN: 14892-97-8 | Product Number: C3577
SCR7 Pyrazine
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Purity: >98.0%(HPLC)
Synonyms:
- 6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(8H)-one
- 6,7-Diphenyl-2-thiolumazine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$125.00
|
1 | 1 | 2 |
|
| 50MG |
$347.00
|
1 | 1 | 11 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3577 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__2N__4OS = 332.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 14892-97-8 |
| Reaxys Registry Number | 306520 |
| PubChem Substance ID | 468591173 |
| MDL Number | MFCD02167478 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 207.0 to 211.0 °C |
| Elemental analysis(Nitrogen) | 16.00 to 17.50 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 209 °C |
| Maximum Absorption Wavelength | 380 nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.59.8000 |
Application
CRISPR Genome Editing
SCR7 Pyrazine enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
References
- Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing of HSV-1 virus in human cells
Application
DNA Ligase Inhibitor: SCR7 Pyrazine
References
- CRISPR-Cas systems for editing, regulating and targeting genomes
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
- An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression
- SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV
- Synthesis and structure determination of SCR7, a DNA ligase inhibitor
- Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner
- Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation
Articles/Brochures
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Specifications
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