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CAS RN: 207557-35-5 | Product Number: C3202
(S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
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Purity: >98.0%(GC)
Synonyms:
- (S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile
- (S)-1-(Chloroacetyl)-2-cyanopyrrolidine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$77.00
|
2 | Contact Us | 19 |
|
| 25G |
$307.00
|
Contact Us | Contact Us | 2 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3202 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__7H__9ClN__2O = 172.61 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 207557-35-5 |
| Reaxys Registry Number | 9045512 |
| PubChem Substance ID | 468591064 |
| MDL Number | MFCD08689902 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 62.0 to 66.0 °C |
| Specific rotation | -150 to -160 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 64 °C |
| Specific Rotation | -147° (C=1.01,CH2Cl2) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H335 : May cause respiratory irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
Transport Information:
| HS Number | 2933.99.9701 |
Application
A Synthetic Intermediate of vildagliptin (LAF-237)
This product is used for the synthesis of vildagliptin (LAF-237) which is a dipeptidyl peptidase 4 (DPP-4) inhibitor used as an antidiabetic agent.
References
- 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties
- Synthesis of Vildagliptin Utilizing Continuous Flow and Batch Technologies
- Synthesis of Enantiomerically Pure N-Acyl Amino Nitriles via Catalytic Dehydration of Oximes and Application in a de Novo Synthesis of Vildagliptin
- Identification, isolation and characterization of potential process-related impurity and its degradation product in vildagliptin
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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