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CAS RN: 78351-75-4 | Product Number: C2884
1-(3-Chloroanilino)-4-phenylphthalazine
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Purity: >98.0%(GC)
Synonyms:
- MY-5445
- 1-(3-Chlorophenyl)amino-4-phenylphthalazine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 20MG |
$105.00
|
2 | 1 | 22 |
|
| 100MG |
$358.00
|
Contact Us | Contact Us | 30 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | C2884 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__4ClN__3 = 331.80 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 78351-75-4 |
| PubChem Substance ID | 253661527 |
| MDL Number | MFCD00209838 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933.99.7900 |
Application
MY-5445: A Specific Inhibitor of Cyclic GMP Phosphodiesterase Type 5 (PDE5)
1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445) is a specific inhibitor of cyclic GMP (cGMP) phosphodiesterase type 5 (PDE5). MY-5445 inhibits platelet aggregation by increasing cGMP content.
References
Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation
M. Hagiwara, T. Endo, T. Kanayama, H. Hidaka, J. Pharmacol. Exp. Ther. 1984, 228, 467.
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine
J. E. Souness, R. Brazdil, B. K. Diocee, R. Jordan, Br. J. Pharmacol. 1989, 98, 725.
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated β-catenin
Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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