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CAS RN: 20350-15-6 | Product Number: B3820
Brefeldin A
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Purity: >98.0%(HPLC)
Synonyms:
- γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid λ-Lactone
- Ascotoxin
- Cyanein
- Decumbin
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$127.00
|
1 | Contact Us | ≥40 |
|
| 50MG |
$436.00
|
1 | Contact Us | 11 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B3820 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__4O__4 = 280.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20350-15-6 |
| Reaxys Registry Number | 25191 |
| PubChem Substance ID | 468590501 |
| Merck Index (14) | 1369 |
| MDL Number | MFCD12913297 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
Properties (reference)
| Melting Point | 204 °C |
| Specific Rotation | 93° (C=2,MeOH) |
| Maximum Absorption Wavelength | 215(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GY8410000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2932.20.5050 |
Application
Autophagy research / Mitophagy research
References
- Erythroleukemia cells acquire an alternative mitophagy capability
- Discovery of Atg5/Atg7-independent alternative macroautophagy
Application
CRISPR Genome Editing / Research on regenerative medicine
Brefeldin A enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
Reference
- Small molecules enhance CRISPR genome editing in pluripotent stem cells
Application
Brefeldin A: A Macrolide Lactone Antibiotic used as an Inhibitor of Protein Trafficking and Secretion
Brefeldin A (BFA) is a natural fungal macrolide lactone antibiotic. Studies has demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. Therefore, BFA has been used as a tool to inhibit protein secretion and study the secretory pathway, effects of BFA on Golgi apparatus and other subcellular systems.
References
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
- Brefeldin A: insights into the control of membrane traffic and organelle structure (a review)
- Brefeldin A: deciphering an enigmatic inhibitor of secretion (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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