Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 118458-54-1 | Product Number: A3497
Arcyriaflavin A
×
![]()
×
Purity: >90.0%(HPLC)(qNMR)
Synonyms:
- 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
- Maleimide Indolocarbazole
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 20MG |
$252.00
|
1 | Contact Us | 26 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3497 |
| Purity / Analysis Method | >90.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__0H__1__1N__3O__2 = 325.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 118458-54-1 |
| Reaxys Registry Number | 4557421 |
| MDL Number | MFCD03452662 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(qNMR) | min. 90.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933.99.9701 |
Application
Arcyriaflavin A: A Potent Inhibitor of Protein Kinases
Arcyriaflavin A is an important member of the indolocarbazole alkaloid family, and was first isolated in 1980 from the slime mold Arcyria denudata.1) This family has potential therapeutic application in the treatment of cancer because of its ability to inhibit protein kinases.2,3) Thera are reports that arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK49 and calcium/calmodulin-dependent protein kinase II (CaMKII).3,4) It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).5) In addition, arcyriaflavin A has been used a key synthetic intermediate of indolocarbazole alkaloids such as staurosporinone [T4000] which is a protein kinase C (PKC) and leucine-rich repeat kinase 2 (LRRK2) inhibitor.6) (The product is for research purpose only.)
References
- 1) Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata
- 2) Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
- 3) Arcyriaflavin A monohydrate
- 4) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitorss
- 5) Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis
- 6) An account of synthetic strategies towards indolocarbazole alkaloids: Arcyriaflavin A and staurosporinone (a review)
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.