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CAS RN: 945667-22-1 | Product Number: A3435
Saxagliptin Hydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile Hydrate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$275.00
|
Contact Us | Contact Us | 18 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A3435 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__5N__3O__2·H__2O = 333.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 945667-22-1 |
| Reaxys Registry Number | 18655324 |
| PubChem Substance ID | 468590297 |
| MDL Number | MFCD26131254 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| Specific rotation | +6.0 to +7.0 deg(C=0.4, Methanol) |
| Water | 5.0 to 6.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 138 °C |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P280 : Wear protective gloves. P272 : Contaminated work clothing must not be allowed out of the workplace. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.99.9000 |
Application
Saxagliptin: A Long-Acting Dipeptidyl Peptidase-4 (DPP-4) Enzyme Inhibitor
Saxagliptin (BMS-477118) is a long-acting dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor which is a new class of anti-hyperglycemic agents. Released into the small intestine in response meals, incretins such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin tropic polypeptide (GIP) are known to be gastrointestinal hormones that promote insulin secretion and suppress glucagon secretion in a glucose concentration-dependent manner. Saxagliptin inhibits the activity of DPP-4 that degrades and inactivates GLP-1 and GIP. Through this inhibition, saxagliptin increases the blood concentration of active GLP-1, and exerts its hypoglycemic effect through increasing insulin secretion and reducing glucagon secretion. (The product is for research purpose only.)
References
- Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
- The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
- Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections
- Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (a review)
- Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review
- Development and validation of a method for simultaneous determination of metformin and saxagliptin in a formulation by RP-HPLC
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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