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CAS RN: 84680-54-6 | Product Number: E1302
Enalaprilat Dihydrate
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Purity: >98.0%(HPLC)
Synonyms:
- N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline Dihydrate
- Enalaprilic Acid Dihydrate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$110.00
|
Contact Us | 1 | Contact Us |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | E1302 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__4N__2O__5·2H__2O = 384.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 84680-54-6 |
| Reaxys Registry Number | 14568894 |
| PubChem Substance ID | 354335632 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 6.80 to 7.80 % |
| Specific rotation [a]20/D | -50.0 to -54.0 deg(C=1, MeOH(calcd.on anh.substance)) |
| Water | 8.0 to 11.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | TW3590600 |
Transport Information:
| HS Number | 2933.99.5300 |
Application
Enalaprilat: The Active Metabolite of Enalapril, an ACE Inhibitor
Enalaprilat is the active metabolite of enalapril [E1010] which is an angiotensin-converting-enzyme inhibitor (ACE inhibitor). Angiotensin I is converted by angiotensin-converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. ACE inhibitors, such as enalaprilat and captopril [C1580], occupy the active center of ACE so that cleavage of angiotensin I is inhibited competitively. The elevation of blood pressure is then attenuated or abolished by diminished production of angiotensin II. (The product is for research purpose only.)
References
- The design and properties of N-carboxyalkyldipeptide inhibitors of angiotensin-converting enzyme (a review)
- Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril
- Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme
- Time-resolved fluoroimmunoassay for the determination of lisinopril and enalaprilat in human serum
- Simultaneous determination of enalapril and enalaprilat in human plasma by liquid chromatography-tandem mass spectrometry
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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