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CAS RN: 168555-66-6 | Product Number: C3009
Combretastatin A4 Phosphate Disodium Salt
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Purity: >98.0%(HPLC)
Synonyms:
- Fosbretabulin Disodium Salt
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 20MG |
$212.00
|
1 | Contact Us | 30 |
|
| 100MG |
$633.00
|
1 | Contact Us | 1 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3009 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9Na__2O__8P = 440.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 168555-66-6 |
| PubChem Substance ID | 354333373 |
| MDL Number | MFCD00943911 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2919.90.3000 |
Application
Antitumor Compound, Combretastatin A4 Phosphate (CA4P)
Combretastatin A4 phosphate (CA4P), a water-soluble antitumor prodrug of Combretastatin A4, is converted to Combretastatin A4 by metabolism. CA4P inhibits microtubule polymerization, thereby inducing mitotic arrest and apoptosis in endothelial cells. It has been reported that CA4P has significant effects on tumor vascularization by disrupting vascular endothelial cadherin.
References
- Antineoplastic agents. 322. Synthesis of combretastatin A-4 prodrugs
- Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
- Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
PubMed Literature
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Safety Data Sheet (SDS)
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Specifications
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