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Published TCIMAIL newest issue No.197
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Xanthine Oxidase Inhibitor - Febuxostat
No.195(March 2024)
Febuxostat (1) is known as an inhibitor of xanthine oxidase. Xanthine oxidase is involved in the conversion of xanthine to uric acid. By inhibiting this enzyme, 1 reduces the production of uric acid.1)
Recently, 1 has been reported to suppress NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome-mediated IL-1β secretion and may be applied in related research studies.2)
References
- 1) Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome
- 2) Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics
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