Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Gelieve het aantal te selecteren
Synthetic Auxin with 1000-fold Stronger Binding Affinity than the Natural Auxin
No.187(August 2021)
A technique to induce degradation of target protein which has AID tag for binding to auxin, because auxin receptor protein (TIR1) acts as a F-box protein constituting SCF complex in ubiquitin-proteasome system is called Auxin-inducible degron (AID) system (Figure 1).1) 5-Adamantyl-IAA (1) has 1000-fold stronger affinity with modified TIR receptor protein than natural auxin.2) These make it possible to induce protein degradation in 1/1000 concentration auxin of original AID system, and a low toxic protein degradation has been reported in mouse and human cells.3)
References
- 1) An auxin-based degron system for the rapid depletion of proteins in nonplant cells
- 2) A Super Strong Engineered Auxin–TIR1 Pair
- 3) A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair
Related Products
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.